Wisepill RT2000 for Bedaquiline containing TB regimens - Conclusions

The Wisepill device shows promise in providing real- time adherence information in a way that is effective and acceptable to the patient. It has the potential to identify lapses in adherence and possibly improve adherence with real-time intervention before these lapses can lead to a negative impact on treatment success. Self-report and pill count depend on patients continuing to attend clinic visits, do not provide data on potential non-adherence in real-time, may be inferior to Wisepill in capturing non-adherence (self- report), and may not provide the reported confidentiality of the Wisepill device. Thus, the use of electronic monitoring devices appears to be applicable to DR-TB treatment in addition to ART, and may have significant advantages to other commonly utilized adherence monitoring methods.

Abstract : Pilot evaluation of a second-generation electronic pill box for adherence to Bedaquiline and antiretroviral therapy in drug-resistant TB/HIV co-infected patients in KwaZulu-Natal, South Africa. 

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A Visit to the Wisepill Manufacturing facility from the Western Cape Health Department

Wisepill Technologies recently invited James Kruger, Director of the HIV AIDS STI & TB Directorate at the Western Cape Department of Health, to visit the Wisepill office in Somerset West followed by a tour of the manufacturing facility where the Wisepill products are produced. The tour showcased the factory processes and the high standard to which each device is manufactured. Mr. Kruger and his team showed great interest in how Wisepill adherence devices are being used in China, India and parts of Africa to manage TB medication adherence. The evriMED devices offer cost-effective adherence monitoring technologies, that enable more patient-centered adherence monitoring options and inform and enable differentiated care to improve health outcomes and reduce TB morbidity and mortality.

Wisepill's "eDOT" solution: evriMED 

Wisepill recently launched an eDOT tool for the management of TB which has been successfully used to assist thousands of TB patients in China and in India so I thought this would be of interest to you.

Wisepill's "eDOT" solution: evriMED

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Two years ago, with support from the Bill & Melinda Gates Foundation (BMGF), Wisepill developed an eDOT tool for the remote management of TB. The result was a tailor-made product called evriMED which has been included by TB Reach and the Stop TB partnership as an example of a quality, World health Organisation approved monitoring technology. 

TB Reach and The BMGF together with USAID and Global Affairs Canada are supporting the TB REACH Wave 6 initiative to fund innovation and research to (i) improve detection, linkage to treatment and reporting of TB, and to (ii) improve TB treatment adherence and outcomes.

Webinar - Leveraging IoT for Medical Monitoring (Tuesday, February 20, 2018 at 9a.m. PT | 12p.m. E)

I also want to take this opportunity to personally invite you to attend a Webinar on the subject of  Real Time Medication Management. Wisepill, is a pioneer in real-time medical monitoring management solutions and will be joining Aeris, a leader in IoT technology, to discuss the technology and the future of Medication Adherence Management. 

Measuring Adherence for antiretroviral therapy (ART) - The META Study

Much has been learned, including that the ‘Wisepill’ is the best tool to date to record adherence. With treatment readily available the greatest challenge for those working to end the HIV epidemic is to ensure that individuals living with HIV remain on treatment.
— Principal Investigator, Assoc Professor Catherine Orrell
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The DTHF team at the Gugulethu Research Offices (GRO) under the direction of local Principal Investigator, Assoc Professor Catherine Orrell, has been involved with this adherence study for the past three years.   The aim is to contribute to the work being undertaken on adherence to antiretroviral therapy (ART) to achieve an AIDS-free generation.     This is the most comprehensive study to have been undertaken to understand ART by stage of HIV infection in sub-Saharan Africa.  There were eleven sites, seven in Mbarara, Uganda and four within the Klipfontein sub-district of Cape Town.   The dissemination of findings to stakeholders took place at UCT on 30th January. Read more ... 

Source: http://desmondtutuhivfoundation.org.za/mea...

Wisepill Related Research Papers

  1. Real-Time Adherence Monitoring for HIV Antiretroviral Therapy, 2010

  2. Improving medication adherence in diabetes type 2 patients through Real Time Medication Monitoring: a Randomised Controlled Trial to evaluate the effect of monitoring patients’ medication use combined with short message service (SMS) reminders, 2011

  3. Optimizing network connectivity for mobile health technologies in sub-Saharan Africa. 2012.
  4. Feasibility and Acceptability of a Real-Time Adherence Device among HIV-Positive IDU Patients in China, 2013

  5. Real-time Adherence Monitoring of Antiretroviral Therapy Among HIV-infected Adults and Children in Rural Uganda, 2014

  6. A pilot study of a nurse-delivered cognitive behavioural therapy intervention (Ziphamandla) for adherence and depression in HIV in South Africa, 2015

  7. Improving Adherence to Antiretroviral Therapy with Triggered Real Time Text Message Reminders: the China through Technology, 2015

  8. A Randomized Controlled Trial of Real-Time Electronic Adherence Monitoring With Text Message Dosing Reminders in People Starting First-Line Antiretroviral Therapy, 2015

  9. Duration of antiretroviral therapy adherence interruption is associated with risk of virologic rebound as determined by real-time adherence monitoring in rural Uganda. 2015

  10. Can Short-Term Use of Electronic Patient Adherence Monitoring Devices Improve Adherence in Patients Failing Second-Line Antiretroviral Therapy? Evidence from a Pilot Study in Johannesburg, South Africa, 2016

  11. SMS reminders plus real-time adherence monitoring improve adherence to antiretroviral therapy in rural Uganda, 2016 

  12. Tenofovir-based oral preexposure prophylaxis prevents HIV infection among women.

  13. The Daily Relationship Between Aspects of Food Insecurity and Medication Adherence Among People Living with HIV with Recent Experiences of Hunger, 2016.

  14. Feasibility, Acceptability, and Tolerability of Targeted Naltrexone for Nondependent Methamphetamine-Using and Binge-Drinking Men Who Have Sex with Men, 2016.

  15. Experiences with HPTN 067/ADAPT Study-Provided Open-Label PrEP Among Women in Cape Town: Facilitators and Barriers Within a Mutuality Framework

Feasibility and Acceptability of a Real-Time Adherence Device among HIV-Positive IDU Patients in China

Feasibility and Acceptability of a Real-Time Adherence Device among HIV-Positive IDU Patients in China

Recently, wireless technology has emerged as a potential tool for monitoring medication adherence in real time. This is noteworthy given the recognized association between late dose-timing and loss of viral suppression. One promising tool, the Wisepill personal medication container (Wisepill Technologies, Cape Town, South Africa), detects the exact date and time whenever the patient opens it to access medication. Read More...

Harvard Research : Real-Time Adherence Monitoring for HIV Antiretroviral Therapy

Real-Time Adherence Monitoring for HIV Antiretroviral Therapy

Current adherence assessments typically detect missed doses long after they occur. Real-time, wireless monitoring strategies for antiretroviral therapy may provide novel opportunities to proactively prevent virologic rebound and treatment failure. Wisepill, a wireless pill container that transmits a cellular signal when opened, was pilot tested in ten Ugandan individuals for 6 months. Read More...

Adherence of pediatric patients to ART in rural Uganda

Qualitative analysis of factors influencing adherence of pediatric patients to ART in rural Uganda

Sub-optimal antiretroviral adherence is a serious problem among people living with HIV (PLWH) that can lead to virologic rebound, resistance to medication regimens, and poor health outcomes. Emerging technologies allow for the detection of potential missed doses in real time as a possible point of intervention. Using these sensory technologies, this test of concept intervention trial was designed to target possible missed doses and initiate just-in-time self-regulation adherence counseling..... Read more

Type 2 diabetes Research published : a study of the effects of Real-Time Medication

Type 2 diabetes Research published : a study of the effects of Real-Time Medication

Improving medication adherence in diabetes type 2 patients through Real Time Medication Monitoring

Of patients who get SMS reminders if they forget their medication, 16% take more of their medication than patients in the control group. The Wisepill real time dispenser and Web application was used to conduct this important study. Read more...